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KMID : 0385019970130010055
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Korean Journal of Laboratory Animal Science
1997 Volume.13 No. 1 p.55 ~ p.61
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Distribution of Neuropeptide-immunoreactive Cells of Substance P and Somatostatin in the Lumbar Dorsal Root Ganglia of the WKY Rat
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Abstract
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Dorsal root ganglion (DRG) cells are primary sensory neurons which contain some biologically active neuropeptides which play a role as neurotransmitters or neuromodulators. This study was performed to observe normal distribution of substance P (SP) and somatostatin (90M) immunoreactive cells and the colocalization of SP and SOM in a single DRG cell of the lumbar IIRGs (L₁-L_6) in the Wistar Kyoto (WKY) rat by immunohistochemstry. About 12.7% of DRG cells contained SP-immunoreactivity, while about 7.5% of DRG cells showed SOM-immunoreactivity. There was no significant difference in percentage of each neuropeptide-immunoreactive cells between each levels of the DRGs (L₁-L_6) (p$gt;0.01). SP and SOM immunoreactive cells were shown in only below size of 600 ㎛². In serial sections, about 5.7% of the SP immunoreactive cells contained SOM immunoreactivity. These cells were generally small in size.
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KEYWORD
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